"It's a flawless day, I'm very happy to score my first goal, the team has played very well and I think we have done a great job", Goal.com quoted Dest as saying.
Antoine Griezmann, on as a substitute, wrapped up the win on a night when young centre-back Oscar Mingueza, Brazilian midfielder Matheus Fernandes and teenage American winger Konrad de la Fuente were blooded in the Barcelona first team.
Also Read | Cristiano Ronaldo Matches Lionel Messi's UEFA Champions League Record With Goal Against Ferencvaros. The game was a draw until the 90th minute, but Juventus' Alvaro Morata scored a header in the added minutes.
Sevilla and Chelsea both won 2-1 against Krasnodar and Rennes respectively.
Dest became the very first United States citizen to score for the senior Barca team. Chelsea striker Olivier Giroud scored the victor in the added time.
Sevilla were taking on Krasnodar in Russian Federation and took a very early lead through Ivan Rakitic.
Manchester United defeated Istanbul Basaksehir, 4-1.
Solskjaer's side are three points clear of both Paris Saint-Germain and RB Leipzig, after an early Neymar penalty gave the French side a 1-0 win over their German visitors.
In the group's other game Ciro Immobile was on target twice, including from a penalty, as Lazio beat Zenit Saint-Petersburg 3-1 in Rome, a result which eliminated the Russians.
Borussia Dortmund defeated Club Brugge, 3-0. The Norwegian's goals sandwiched a fine free-kick from Jadon Sancho.