Skinner will take charge of the team until the end of the 2022-23 season.
Prior to that, Rehanne held the position of assistant manager at Arsenal where she worked for three years alongside Laura Harvey during a highly successful period for the team from 2010, lifting two Women's Super League titles, two Conti Cups and one FA Cup, as well as reaching the UEFA Champions League semi-finals on two occasions.
"This is a brilliant opportunity and I am sure England teams will feel the benefit in the future of having another WSL head coach who understands our commitment to furthering the player pathway and can continue to build on the excellent relationship we enjoy between the domestic and global game". However, the Lilywhites produced a decent performance in playing out a 2-2 Continental Cup draw at Arsenal only yesterday, with Hills enthusing: "I'm so pleased that the performance has finally come together".
Tottenham women's head coaches Karen Hills and Juan Amoros have been sacked, the club announced on Thursday.
Karen Hills and Juan Amoros leave Club. "Everybody at the Club wishes both Karen and Juan the best for the future", the statement read. This season they made headlines when securing the signing of the season in US women's football superstar Alex Morgan, who joined on loan.
"I am really excited to be joining Tottenham Hotspur and can not wait to get started in the WSL", Skinner said in a statement on the club's website.
She returned to the United Kingdom in 2016 with the Wales Women's National Team as assistant manager before taking up her role in 2017 with the FA, her second spell at the governing body having coached England national youth teams for seven years earlier in her career.
"I have really enjoyed my time at The FA, working alongside some wonderfully talented people and with players who have done so much to put women's football and our England teams in the spotlight".
The 45-year-old masterminded three promotions in the space of five years, with the club admitted to the women's top flight at the start of the 2019-2020 season.