Leicester are due to face Palace on Saturday but a local lockdown has been imposed on the city of Leicester by UK Health Secretary Matt Hancock due to a spike in coronavirus cases.
Vardy is without a goal in those three games, but has scored 19 times in 33 matches this season, to go with six assists.
Speaking after last night's 1-0 defeat to Burnley, Hodgson said he was relaxed about any potential change of venue.
Leicester City manager Brendan Rodgers says his side "will react accordingly" if lockdown measures are extended locally. "I'm perfectly happy to let the Premier League take care of that", said Hodgson.
"Playing against a top team, who are very good, I thought we dominated the game in the first half and we had opportunities".
"As a football club, we're very protected, the players and everyone, we're still in a bubble where the players are in, they're tested twice a week", Rodgers said after Sunday's FA Cup quarter-final loss to Chelsea.
Leicester are now third in the Premier League and on course for a Champions League place but they have yet to win since football restarted in June.
"It's all hypothetical at the moment so there's nothing really to answer on. We will just continue our work", the Leicester boss said.
"Nothing's changed really in terms of how we've been working thus far throughout this situation".
"We have to have agility in this period", he added.
"There's lots of focus on Jamie, but this is not just about Jamie, this is the responsibility of the team and it's my responsibility to find ways in which we can find ways to increase our goalscoring", he told a news conference.
"You're always concerned nationally in terms of COVID and trying to ensure the rates are down, but I think we're in a position here at the club, like most other clubs, we're very much protected".