The Prime Minister gathers his new team in Downing Street shortly after 10am as he attempts to move on from the dramatic resignation of his former chancellor Sajid Javid.
There were mixed fortunes for the region's MPs during a day of high drama in Downing Street.. "Sad not to be part of it".
Newcomers at the cabinet meeting on Friday will include Anne-Marie Trevelyan, who replaces Alok Sharma as worldwide development secretary; Amanda Milling, who is minister without portfolio and chairwoman of the Conservative Party; and Suella Braverman, who takes on the role of attorney general after the prime minister asked Mr Cox to step down.
The government said Thursday that Alok Sharma, previously in charge of global development, would become business secretary and also take charge of COP26.
Besides Javid's exit, perhaps the greatest surprise in the Cabinet reshuffle is the firing of Northern Ireland Secretary Julian Smith, who had success securing a deal to end a three-year suspension of the local government. Witham MP Priti Patel also remains as home secretary.
The role of Dominic Cummings in Sajid Javid's decision to step down.
Special Advisers across government are going to be brought under the yoke of No. 10 and there are bound to be more job losses at that level in the coming hours.
Mr Javid accused the Prime Minister of setting conditions "any self-respecting minister" would reject - seen as a thinly veiled swipe at his successor.
This is now being replaced with an integrated Number 10-Treasury team of advisers at the top of that structure.
Johnson, who had wanted to minimize any disruption from the cabinet reshuffle, quickly appointed Javid's deputy Rishi Sunak, a loyal supporter of the prime minister who has often been put in front of the cameras to sell government policy.
And he told Mr Johnson in his resignation letter that he believed it was "important as leaders to have trusted teams that reflect the character and integrity that you would wish to be associated with".
He used Thursday's reshuffle to announce Alok Sharma as his new business and energy minister, with a new responsibility for running the United Nations climate talks in Glasgow in November.
Oliver Dowden has become a full cabinet member as culture secretary having previously attended the meetings as paymaster general.
George Eustice was promoted to environment secretary from his previous role in the same department.
Former defence secretary Penny Mordaunt will return to Government as Paymaster General in the Cabinet Office.
But investors piled into sterling in the hope Sunak - chief secretary to the Treasury and an ally of Number Ten - will deliver a more radical budget to kick-start the economy.