Neymar of Brazil reacts after stumbling during their worldwide friendly match against Peru at the Los Angeles Memorial Coliseum, Los Angeles on Tuesday.
A goal in the 85th minute from Luis Abram handed Brazil their first defeat since the 2018 FIFA World Cup, a run consisting of 17 matches without loss.
Although the Selecao arguably had the better chances against Peru, whom they beat in the final of the 2019 Copa America, it was not to be for Tite's men in the early hours of Wednesday.
Although Richarlison was busy up front, forcing Pedro Gallese to tip one fierce shot round the post, Brazil never looked in full control of the game.
Leandro Paredes scored from the penalty spot in the 33rd minute.
And Lautaro completed his hat-trick with 39 minutes on the clock as he took advantage of sloppy defending from the Mexican defence and powered the ball past Guillermo Ochoa in goal.
Eight players were shown yellow cards in a match that rarely lived up to its "friendly" billing, but the game will be remembered largely for the brilliant finishing that brought the 22-year-old Martinez his first worldwide hat-trick.
But it was the 22-year-old Martinez who grabbed the headlines with a clinical exhibition of finishing which took his worldwide goals tally to nine in 13 appearances.
Mexico has overcome all obstacles that have been thrown in their way since Gerardo Martino took charge of the team, and they want to keep the pace; however, they will go against one of their most complicated rivals, the fist big test for El Tri since the arrival of the Argentine coach to the bench.
Lionel Scaloni was delighted with the application of his Argentina side against Mexico, claiming they played "a ideal game" in a 4-0 victory.