The England manager has chosen to refresh his team at full-back after Saturday's comprehensive 4-0 win over Bulgaria at Wembley. Sancho came off the bench against Bulgaria on Saturday and Southgate.
It should be more of the same when Kosovo visit Southampton on Tuesday although one of UEFA's youngest members are England's closest challengers with eight points from four games after a shock defeat of Czech Republic. Can Harry Kane bring his England form to the Premier League with Tottenham?
Manchester City winger Sterling, 24, has seven goals in six games for club and country this season, while Manchester United's Rashford, 21, has already scored seven goals for England.
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The World Cup Golden Boot victor is up to 25 in 40 games for the Three Lions and Southgate thinks he could threaten Wayne Rooney's all-time record of 53.He said: "There's a reason that only Bobby [Charlton] and Gary [Lineker] and Wayne have got [to around 50 goals], because it's such a hard challenge to stay fit, the number-one choice, focused and motivated for the long period that you need to be able to get the games and get those goals."But if anybody has that strength of mentality, it's Harry".
"I remember going to Spain [in October 2018] and thinking: 'Well, a really tough game.' But, actually, you look at our front three and their front three on the night and I felt that we were strong".
Asked if his forwards know they can be among the best, Southgate replied: "They have great humility". So, I think he's still a work in progress.