According to oddsmakers, the Astros are favored on the road, as they are getting odds of -400 to win.
Houston edged Baltimore 3-2 on Friday night and then crushed the Orioles on Saturday.
Houston starter Justin Verlander lasted just five innings and allowed four runs on a season-high nine hits.
Houston has won eight straight, the longest winning streak in the American League, while Baltimore has dropped five in a row - all at home.
With Michael Brantley batting in the ninth inning of the Astros' game in Baltimore, Houston was threatening a rally against Mychal Givens with two on and nobody out in the inning.
"It was a fun way to win a game, a fun way to get out of the homestand", said Jace Peterson, who had three hits and two RBIs. The right-hander struck out 11 to reach double digits in a fifth consecutive outing but also gave up at least one hit every inning.
The Orioles are 17-43 on their home turf. Baltimore has Asher Wojciechowski on the mound today.
Houston put up an incredible 25 hits on Saturday in the win. He is 2-5 on the year with a 4.89 ERA. For Bregman, it was a two-run homer, and Alvarez followed with a solo shot for an early 3-0 lead.
Yuli Gurriel pitched in with an RBI double in the fifth inning and George Springer made it 13-1 with his two-run double, also in the fifth. The Orioles will try to cut that down Sunday before heading to face the Yankees on Monday - a team that hit 16 in three games against the Orioles earlier in this homestand.
The Orioles are in a tough spot regarding pitching heading into Sunday's game. Wojciechowski is another example of the very bad Baltimore pitching. He gave the Orioles two good starts recently but struggled in his last two. They just have to hope the Astros have swing fatigue from Saturday's performance.