Why Women's Risk of Alzheimer's Differs From Men's

Alzheimer’s Disease Affects More Women Than Men – New Research Revealed Why

More women living with Alzheimer's than men

"Understanding how different biological processes influence our memory is a really important topic", Shokouhi said.

According to a collection of new studies reported at the Alzheimer's Association International Conference, the expedited progression of Alzheimer's in the female brain seems to revolve around not only biological differences but also social and genetic factors.

The association's chief science officer, Maria Carrillo, said that just because women live longer, it does not mean that this is the reason why two-thirds of Alzheimer's cases in the US are found in women.

Other researchers presented findings at the conference showing several newly identified genes which seem to affect the disease risk depending on someone's sex.

The new studies add more evidence and potential explanations for suspected variations between how men and women develop the disease.

A study from the University of Miami found evidence that sex-specific genes for either women or men can be linked to Alzheimer's risk.

Washington D.C. [USA], July 18 (ANI): While the accumulation of proteins in the brain is a marker to indicate the onset of Alzheimer's, a new study analysed the ways in which these proteins spread, that might help in describing why the disease is more prevalent in females than males.

However, women who have early-stage AD could go undiagnosed as they generally do better on verbal tests than men, which could mask any Alzheimer's damage.

Researchers at Vanderbilt University have discovered that tau, a protein that destroys nerve cells, is more spread out and diffuse on the brain of women with mild impairment, implying that more areas of the brain were affected. Using scans from 301 people with normal reasoning skills and 161 people with mild impairment, they mapped where tau was deposited and correlated it with nerve networks.

Using scans on more than 1,000 older adults, they found gender differences in how the brain uses sugar, its main energy source.

It's always been known that women do better on tests of verbal memory - skills like recalling words and lists. This might compensate for any damage caused by dementia, making it less likely that they would be diagnosed by tests that involve verbal skills. This study observed more than 6,000 women born between 1935 and 1956 and determined that working outside the house appears to better for the brain. "The graph analysis does something similar to show how tau spreads from one region to another", said Sepi Shokouhi, PhD, assistant professor of Psychiatry and Behavioral Sciences and lead investigator for the study.

Researchers don't know yet exactly how these genes affect risk - or by how much.

Seven other genes seem to have a different effect on risks in men versus women.

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