It was also a display of muscle-flexing by City, Liverpool and Spurs that will have been noted by the likes of Barcelona and Juventus, the two continental heavyweights most likely to stand in the way of an English triumph in the final in Madrid on June 1.
"To have four teams in the last eight is great for England", Liverpool midfielder Milner said. The other possible opponents - Ajax, Tottenham and Liverpool are viewed as tough sides, although a better alternative to facing City or Juventus.
"We'll have to work all of that out as that goes on".
The other clubs to have booked their spots are European giants Juventus and Barcelona, and surprise packages Porto and Ajax - the latter of whom dethroned Real Madrid last week.
The win against of Bayern Munich had underscored the impression that Jürgen Klopp's side are a team going places, but James Milner could not help dwelling on what might have been.
"And it's not like any of us have had easy teams to play against".
"So when they don't fire, it really affects the team".
Pep Guardiola's free-scoring City are the favourites with the bookmakers after their 10-2 aggregate thrashing of German club Schalke in the last 16.
Mourinho knows from firsthand experience how emotional all-Premier League encounters in Europe can be, having overseen several titanic clashes against Liverpool in the Champions League during his first stint as Chelsea manager, including the semi-finals in 2005 and 2007 respectively. The following season the Reds overcame Arsenal, which included a thrilling 4-2 second-leg at Anfield, however Chelsea squeaked through in extra-time during the semi-final second-leg.