Ben Youngs will become England's most-capped halfback after being selected to start the Calcutta Cup clash at Twickenham.
Eddie Jones and England will hope a Six Nations title is on the line when they face Scotland on Saturday, but they will only have the chance to lift the trophy if Ireland do them a favour and win in Cardiff before that.
There are two changes to the forwards as flank Mark Wilson replaces Brad Shields and prop Ben Moon comes in for Ellis Genge.
Scotland beat England at home a year ago, but haven't won at Twickenham since 1983.
Sean Maitland and Byron McGuigan replace injured duo Blair Kinghorn and Tommy Seymour in the back three, and Sam Johnston is included at centre with Pete Horne dropping out. Chris Harris returns from injury to cover the outside backs from the bench.
"We're delighted to bring back Hamish into the starting line-up", said coach Gregor Townsend.
"We have to build on the positive aspects of our performance against Wales". "The next step is making that pressure count on the scoreboard, more regularly. At times against Wales we weren't aggressive or accurate enough so that has been a focus for us this week in training".
Scotland (v England at Twickenham, Saturday, 5pm): Seam Maitland; Darcy Graham, Nick Grigg, Sam Johnson, Byron McGuigan; Finn Russell, Ali Price; Allan Dell, Stuart McInally©, WP Nel, Ben Toolis, Grant Gilchrist, Sam Skinner, Hamish Watson, Magnus Bradbury.