It's been a tough few days for Meghan after her father Thomas Markle shared extracts from a heartbreaking five-page letter - which was allegedly written by the Duchess of Sussex herself - with the Mail on Sunday, showing the depths of his daughter's grief over their estrangement.
There is historical resonance and poignancy in the plight of a princess, married into the British royal family, who enjoys public adulation yet suffers private pain.
The Hollywood star is a friend of Harry and Meghan and he and his human rights lawyer wife Amal attended the royal wedding in May past year.
She later added, "I doubt #GeorgeClooney would ghost his mother for no legitimate reason". Something I will never understand.If you love me ... allow us to live our lives in peace.
Samantha yesterday also unleashed a string of cruel tweets, saying: "If I had 600 mill she would care". "She can write all the fake, contrived letters she wants to show off her penmanship but that's all it is".
The pair's relationship is now at breaking point after Meghan claimed in the letter that Thomas has not contacted her, despite him strongly denying this.
"So to hear about the attacks you've made at Harry in the press, who was nothing but patient, kind, and understanding with you, is perhaps the most painful of all".
"The only thing that helps me sleep at night is the faith and knowing that a lie can't live forever".
The media's treatment of Markle has not been unlike what Diana experienced, as Clooney noted.
However, it seems the relationship might be beyond fix if the Duchess is considering taking legal action against her dad.