Two Arleigh Burke-class destroyers - the USS Spruance and the USS Preble - conducted a freedom-of-navigation operation on Monday, sailing within 12 nautical miles of Chinese outposts in the contested Spratly Islands.
Beijing has voiced its "strong dissatisfaction" with the United States on Monday after two U.S. warships sailed near islands claimed by China in the South China Sea.
"We respect all countries' right for freedom of navigation and flight under global law, but we firmly oppose any action to jeopardize the sovereignty and security of countries under the pretext of freedom of navigation", Hua said Monday.
The spokesperson also demanded the USA stop what she called its "provocative actions", adding her country will take necessary actions to protect state sovereignty.
"The relevant actions of the USA warships violated Chinese sovereignty and undermined peace, security, and order in the relevant sea areas".
The US Navy sent two guided-missile destroyers to challenge China in the South China Sea, and Beijing is outraged.
The operation was the latest attempt to counter what Washington sees as Beijing's efforts to limit freedom of navigation in the strategic waters, where Chinese, Japanese and some Southeast Asian navies operate.
China claims most of the energy-rich South China Sea, as do several of its neighbors, including the Philippines, Vietnam, and Taiwan.
Vietnam, the Philippines, Brunei, Malaysia, Indonesia and Taiwan have competing claims in the region. In September, a Chinese warship came within just 45 yards of a US destroyer, raising concerns about the possibility of tensions boiling over into conflict.
The two countries have traded barbs over what U.S. said was Beijing's military installation building on artificial islands and reefs.
Top US officials have attacked China for everything from human rights abuses to cyber espionage in America.
The United States is expected to keep pressing China on longstanding demands that it reform how it treats American companies' intellectual property in order to seal a trade deal that could prevent tariffs from rising on Chinese imports.
China says the bases are essential for self-defense and accused the United States of ramping up tensions in the region by sending battleships and warplanes close to the disputed islands.