The champions recovered from a chaotic 3-3 draw at home against Parma with a straightforward victory and a more composed performance at MAPEI Stadium.
Consigli denied Federico Bernardeschi just before the break with a Khedira header flying wide.
The seven-time Serie A champions had been held by promoted Parma last week despite the Portugese forward's double, but leave second-placed Napoli trailing after Carlo Ancelotti's side were held to a goalless draw at Fiorentina on Saturday.
Sassuolo almost took a 14th-minute lead following a scorching shot from outside the box by Manuel Locatelli, but Wojciech Szczesny palmed off the danger.
But the Portuguese star jumped highest after 70 minutes to meet Pjanic's corner for his fourth goal in his last three league games with Can coming off the bench to score from a Ronaldo assist.
Can then fired a low shot into the corner to make it 3-0 on 86 minutes following some good link-up play between Ronaldo and Dybala.
What does it mean?
The OId Lady remain 11 points clear of nearest "challenger" Napoli and haven't suffered defeat at all this season as they chase their eighth successive Scudetto.
Juve might have lacked a creative presence in and around the penalty area with Dybala being dropped but Khedira's all-action display ensured the Argentina playmaker was not missed.
- Sami Khedira has scored four Serie A goals against Sassuolo, his joint-record against an opponent in the Italian top flight (level with Udinese).
Since moving to Turin from Real Madrid in a €100million (£88.5m) move last summer, the 34-year-old Ronaldo has scored 18 goals in 23 league appearances, and 20 in 31 appearances in all competitions overall.