Myriad study shows breast cancer recurrence test can predict therapy responses

SABCS Breast Cancer Outcomes Worse for Blacks Despite Similar Gene RS

Body fat and breast cancer

The CDC says that more than 53,000 new cases were diagnosed in 2015, with the endometrial cancer (which begins in the lining of the uterus) being the most common type of uterine cancer diagnosed nationwide.

More than 250,000 women in the United States were diagnosed with invasive breast cancer in 2017, according to the American Cancer Society.

"Our results suggest that biological differences may contribute to the significantly different outcomes of black women compared to others with breast cancer", Albain said in a statement. The disease claims the lives of about 40,000 people each year.

Using dual-energy x-ray absorptiometry (DXA) to assess body fat in more detail, elevated breast cancer risk was found in postmenopausal women with normal BMIs but high measurements of whole-body fat, percentage of whole-body fat, and trunk fat mass, according to researchers led by Neil Iyengar, MD, of Memorial Sloan Kettering Cancer Center in New York City. Findings released from the TAILORx study in June 2018 showed no benefit from chemotherapy for 70 percent of the women in the trial.

The company also said the test can predict those who will be unlikely to see benefits from extended endocrine treatments over a five-year period and can forgo therapy, as well as offer a long-term prognosis on the risk of disease recurrence. "We've long known that so-called intermediate-risk patients may indeed have significant risk of late distant recurrence", said V.K. Gadi, MD, PhD, medical oncologist, University of Washington/Fred Hutchinson Cancer Research Center, and an author of the analysis. About 84 percent of the patients were white, 7 percent were black, 4 percent Asian and 4 percent were of other or unknown race. Compared with non-Hispanic ethnicity, Hispanic ethnicity was generally associated with better outcomes.

The types, use and length of treatments were similar between both black and white patients and between Hispanic and non-Hispanic patients.

The association was even stronger for risk of estrogen receptor (ER)-positive breast cancer in women with the highest levels of whole-body fat (HR 2.21, 95% CI 1.23-3.67, P=0.002), percentage of whole-body fat (HR 2.17, 95% CI 1.29-3.66, P=0.01), and trunk fat mass (HR 1.98, 95% CI 1.18-3.31, P=0.003), the study found. These possible side effects should be further researched and taken into consideration when counseling patients, Leon-Ferre said. There were three arms in the trial with patients in two arms receiving different dosages of oxybutynin and patients in the third arm receiving a placebo.

Dr. Ann Partridge is a breast medical oncologist at Dana-Farber Cancer Institute in Boston and wasn't involved in the new research. But she said she wasn't surprised by the findings and agreed that black and white patients in the study may have adhered to hormonal pill therapy differently.

"There's no doubt that the incidence and mortality of uterine cancer, specifically endometrial cancer, is higher in African-American women", he said. According to the CDC, there are lots of factors because of which the nation is seeing more number of patients with uterine cancer, but obesity is the primary reason behind this problem.

"We have to chip away at it all, increase our understanding of disease differences and not lump [factors together] as much as we do", Partridge said.

Women with excess body fat, even if they have a healthy BMI, could still have an elevated breast cancer risk, an worldwide study has found. Research presented at scientific conferences typically hasn't been peer-reviewed or published, and results are considered preliminary.

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