The last five winners of the Walter Camp have gone on to win the Heisman, but only five Heisman winners have failed to win Associated Press Player of the Year since the award started in 1998.
The O'Brien Award was initially given to the top player in the Southwest before going to a quarterback-only honor in 1981.
The Heisman Trophy victor will be announced Saturday night, December 8 in New York City.
If Murray wins, it would be OU's seventh Heisman Trophy.
No. 4-ranked OU, which behind Murray leads the nation in points per game (49.5), yards per game (577.9) and yards per play (8.7; FBS record is 8.6), will make its 52nd bowl appearance when it takes on No. 1 Alabama in the College Football Playoff Semifinal at the Capital One Orange Bowl on December 29 at 7 p.m. CT. Only twice since 2002 has the AP Player of the Year not won the Heisman, Nebraska's Ndamukong Suh in 2009 and Stanford's Christian McCaffrey in 2015.
Murray, a 5-foot-10, 195-pound junior from Allen, Texas, won the award in his final year as a college athlete. Earlier in the day, Murray was also announced as the AP Player of the Year. The Oakland Athletics took Murray with the ninth pick in the Major League Baseball draft in June.
Murray won over Tagovailoa and Minshew for the O'Brien.
After a record-setting season, Murray is set to take home a list of awards, starting with this one. He went on to become one of three 4,000-yard passers in the nation and threw for 40 touchdowns. He also added 190 yards and five more touchdowns on the ground, giving him the single-season school record for most combined touchdowns with 42.
"It's been a long journey with a lot of waiting, but I think it's all been worth it", Murray said.