Steven Gerrard's side led three times in Russian Federation but conceded two goals in a minute, as well as an own goal, on the way to going down 4-3 in Russian Federation.
"Normally, coming away to a place like this to get three goals, you at least expect to get a result".
Gerrard said: "I'm very disappointed with the result".
Fans were angry with the way their side performed on the night, however, one man was singled out on Twitter for some praise. I think you saw two sides of our performance today - I think we attacked very well and I thought we were very risky and countered very bravely and got our rewards for that to be in control of the game at half-time. However, they are now level with Spartak after tonight's loss. "But we are bitterly disappointed with how we defended tonight".
Rangers had victory in their sights at the break as they emerged from a rollercoaster first half with a slender advantage.
Moments after Middleton's first European goal gave Rangers the lead for a third time after 42 minutes, Alfredo Morelos had a strike ruled out for a debatable offside call from the Croatian officials.
What do you think of Gerrard's comments, and did Rangers really defend that poorly? "When you get a little bit older you learn to play the game positionally". At times they might make mistakes but you trust them in the second half to defend better. We had a awful five minutes and paid the price. We should have had four goals, but that is another story.
Worrall, who joined the Gers on a season-long deal on transfer deadline day, remained as an unused substitute against Spartak Moscow despite playing a part in Rangers' prior five games across all competitions.
He said: "It's still wide open, it will go to the wire which is what we predicted at the beginning".
"We knew it was going to the wire but tonight's result makes the challenge a bit more hard".