The iconic Agoura Hills home used on The Bachelor and The Bachelorette was in path of the fast-moving Woolsey blaze.
The lower house has reportedly been destroyed, while flames have reached the back patio of the main house and are continuing to advance.
Bachelor producer Robert Mills also confirmed the "Villa de la Vina" property was in "grave danger" in a tweet.
Neither series is now in production at the home, according to show producer Warner Bros TV, which said executive producer Bennett Graebner earlier confirmed the back patio is burning and flames are moving towards the house.
The fire also swept through the historic Western Town at Paramount Ranch, also in Agoura Hills.
The Woolsey fire is quickly moving toward the cities of Calabasas and Malibu.
A number of celebrities - including Kim Kardashian West, Scott Baio and Rainn Wilson - were among those forced to evacuate their homes.
Caitlyn Jenner said in an Instagram post earlier today that she was "safe and sound" and unsure if her home was still standing, although multiple outlets are reporting that the beach-side property has been destroyed by the fire. "All residents must evacuate immediately".