The former captain's one-off return for the Wayne Rooney Foundation global against the USA will dominate the manager's press conference this afternoon but Southgate is again planning to select a youthful party with Jadon Sancho and James Maddison keeping their places.
The 33-year-old is now set to return for one last outing.
Rooney has not played for his country for nearly two years and Press Association Sport understands he will make a late substitute appearance in a game which will be known officially as the Wayne Rooney Foundation International.
FA chiefs have faced accusations they are devaluing global football by recalling Rooney but Kane was in no doubt about having his predecessor as England skipper involved one last time. "It's a real good thing for everyone to be a part of", he added. He was a fantastic player for England and it's fine by me if we want to celebrate his achievements.
"That's not to say that Wayne does not deserve a tribute but give him a presentation, don't just give caps away, which is wrong and also denies a young player a chance as well".
"You can come on with two minutes to go because you need a change - I've played when we've changed the whole team at half-time".
"But I can understand why some people might think it makes the game a bit of a circus - and England have got an important game (a crucial Nations League decider against Croatia) three days later".
Tottenham striker - and current Three Lions skipper - Kane sees differently, however, and when asked whether Rooney should take the armband against the United States, he said: "Yes, of course".
Everton centre-back Michael Keane is recalled to the squad for the first time in a year.
Harry Kane said: "Yes of course".
The DC United forward, who has scored 53 global goals and made his last worldwide appearance in a 3-0 victory over Scotland in November 2016, will be used as a second-half substitute.