The US command also claimed to assess that "this airstrike did not injure or kill any civilians".
The air strike, which was launched on Friday, occurred near the al-Shabab-controlled community of Harardere in Mudug province in the central part of the country, the US Africa Command announced on Tuesday.
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The US said the attack was carried out as part of a joint effort with Somali forces to hit the al-Shabab group.
In March of 2017, President Donald Trump authorized the United States military to carry out precision strikes targeting al-Shabaab in an effort to bolster the Federal Government of Somalia. The last air raid in November 20-17 killed more than one-hundred al-Shabab militants.
The group, which is affiliated with al-Qaida, has proved tenacious and regularly carries out deadly attacks against high-profile targets such as hotels and checkpoints in the capital and other cities.
"Air strikes reduce Al-Shabaab's ability to plot future attacks, disrupt its leadership networks, and degrade its freedom of maneuver within the region", Africa Command said in a statement.
It also came ahead of the first anniversary Sunday of a truck bombing that left more than 500 dead in Mogadishu, the worst ever attack in Somalia blamed on Al-Shabaab.
"A large concentration of Shabab fighters a significant distance from its typical support zone in Jubba River Valley demonstrates the al-Qaida branch's resilience across the country", wrote Bill Roggio and Alexandra Gutowski for the Foundation for Defense of Democracies' Long war Journal.
Al-Shabab, which has been fighting to establish an Islamic state in Somalia for nearly a decade, continues to hold parts of the country's south and central regions after being chased out of Mogadishu several years ago.