Henry has been confirmed as the coach of former Ligue 1 champions AS Monaco, following the departure of Leonardo Jardim.
Monaco vice president and chief executive officer Vadim Vasilyev is confident the 41-year-old World Cup victor can make an impact in the dugout.
Patrick Kwame Ampadu, a coach at Arsenal's academy and father of Chelsea and Wales player Ethan Ampadu, will join Henry's coaching staff, alongside Benfica Under-23 coach Joao Carlos Valado Tralhao.
Henry started his career at Monaco, and has been working as assistant to Belgium boss Roberto Martinez.
A statement on the club's website read, "AS Monaco announces the appointment of Thierry Henry as coach of the professional team".
Indeed, Henry's task is a hard one as he is charged with turning around the form of a side which have picked up only six points from nine Ligue 1 matches this season.
"I am very happy to come back to Monaco and extremely determined to meet the challenges ahead". The 2016/17 Ligue 1 winners are fighting in the relegation spots and have failed to open their account in the Champions League. I cannot wait to meet the players to start working together, '' Henry explained.
Henry has signed a three-year deal with Monaco and spoke of his delight at the move this morning.
'Thierry is both aware of the task ahead and eager to start his new job.
Henry was a World Cup victor with France in 1998 and won the European Championship two years later, scoring 51 goals in 123 appearances for Les Bleus.
Monaco chief executive officer Vadim Vasilyev, said Henry could "count on our trust and all our support to bring a new dynamic to the team and carry out the mission".