Last season, 19 of Leeds' 46 league games were selected for Sky TV coverage, which Radrizzani says puts the club at a disadvantage.
"It is really not sustainable to stay in the Championship".
The Championship is blighted, he said, by EFL money being too little and shared with clubs in Leagues One and Two, and the "huge gap" with clubs relegated from the Premier League benefitting from multimillion-pound parachute payments.
Leeds struggled in his first season and finished 13th in the table, prompting Radrizzani to sell around 12 per cent of his shares to the investment arm of the San Francisco 49ers earlier this year.
The Italian says clubs like Leeds being "watched by 500,000-600,000 people live on Sky" but only getting £2m-£2.5m from the league for having their games televised - the rest made up via the EFL - "actually penalises us".
"Maybe they need to consider another way to create value, Premier League 2 or something, that is sustainable even for the clubs who are not promoted".
'I think other chairmen love to open a discussion because I think the time is getting ready to consider what to do to move forward, and don't have a crisis every two years with every club going bankrupt or changing ownership'.
Radrizzani said he does respect the league's financial fair play rules, which limit a club's losses to £13m per season but argued they did not make the Championship sustainable: "It's hard to be in a league where we make losses because there is not enough income generated from media rights", he said.
Radrizzani talked of implementing a five-year plan when he first invested in the club, saying he would sell up if Leeds remained in the Championship beyond that timeframe, but in an interview with the YEP in August he highlight the pressure of managing annual losses at Elland Road.
Asked if he had already held meetings with other club owners to plot a course for revolt, Radrizzani - owner of emerging TV rights contenders Eleven Sports - warned: "No, it's just my belief, you should ask other clubs".
"We're always on TV, maybe more than 20 times".
"After a year ago, I really wanted to have a manager to give us strong leadership, to be a catalyst for the whole club and the players".