The crew had to abort.
In statements by both Russian Federation and NASA the crew is said to be in "good condition", and no serious injuries have been reported.
Astronaut Nick Hague and cosmonaut Aleksey Ovchinin were rescued without injuries in Kazakhstan.
NASA says that two astronauts from the USA and Russian Federation are in good condition after an emergency landing following booster rocket failure minutes after the launch.
A Soyuz rocket meant to carry a Russian cosmonaut and a U.S. astronaut failed during launch and plummeted back to earth in the skies above Kazakstan on Thursday morning. The footage showed the ISS crew being severely shaken around as the booster failed mid-air before the feed cut out. Hague, one of the two crewmembers on today's launch, was scheduled to take part in two upcoming spacewalks on October 19 and 25 to replace batteries attached to the outside of the space station.
The duo had lifted off from the Russian-operated Baikonur Cosmodrome in Kazakhstan.
The politician has clashed with the U.S., suggesting American astronauts should use trampolines instead of Russian rockets to reach the ISS after Washington imposed sanctions over Moscow's 2014 annexation of Crimea.
A United States astronaut and a Russian cosmonaut are alive after a failure during a mission to the International Space Station. The mission would have been Hague's first space flight.
Moscow immediately suspended all manned space launches, the RIA news agency reported, while Roscosmos chief Dmitry Rogozin said he had ordered a state commission to be set up to investigate what had gone wrong. He added that a "thorough investigation into the cause of the incident will be conducted". Everything had been going quite smoothly for Roscosmos ahead of the freaky hole discovered in one of their Soyuz spacecraft which was (and still is) attached to the International Space Station. Roscosmos has earned billions of dollars in fees ferrying astronauts into orbit since NASA retired its fleet of space shuttles in 2011.
The three astronauts now on board the space station have been informed of the failed launch and their schedule for the day is being reshuffled, since they'll no longer be able to greet the incoming duo. Spacewalks take extensive, long-term planning, so the crew and their teams back on Earth will have to come up with an alternative plan.
Those spacewalks had already been delayed after the Japanese cargo vehicle carrying the new batteries ran into a series of launch delays in September.
"We have plenty of supplies on board the station to support the crew and they're going to continue to do work", NASA spokesperson Kelly Humphries told Space.com.
Forty-two minutes after liftoff, NASA tweeted that the Soyuz capsule had landed back on Earth. But exactly when the astronauts will be sent home is still unclear. He didn't say if he suspected any of the current crew of three Americans, two Russians and a German aboard the station. The space station and its crew depend heavily on missions supported by the rocket.