In the year since he made his first appearance at the UN as president, Trump has sparked trade wars with allies and adversaries alike, delivered a stunning diplomatic détente with North Korea and withdrawn the United States from yet more multilateral agreements and commitments.
President Trump also took aim at the United Nations regarding aid programs he believes are contrary to America's interests.
The leaders of Iran are sowing chaos, death and destruction, disrespecting their neighbours' borders and sovereignty, and plundering their country's resources.
But the real estate mogul turned populist leader was comparatively subdued a year after he stunned the global body with his bellicose language on North Korea, including a threat to "totally destroy" Kim Jong-un's state.
Trump had called Kim a "rocket man" bent on nuclear destruction in his United Nations speech previous year.
Mr Trump used his speech to call for global trade reforms and insist that his main objective as president is to protect American sovereignty.
"None of us can remain silent to the arbitrary cancellation of commercial agreements and the use of economic sanctions as weapons", Mr Erdogan said his country's address in the General Debate.
Trump also attacked China for trade violations and the theft of U.S. intellectual property, saying America would "no longer tolerate such abuse".
Trump's pull-out from the deal was met with intense criticism from world leaders, especially those of the other countries - Britain, France, Germany, China and Russian Federation - that brokered the accord.
Those comments came only hours after Mr. Trump on Twitter said he was sure Iran's president, Hassan Rouhani, is a "lovely man", comments that perplexed some given Rouhani's reputation as a brutal leader.
He said 'we are standing up for America and for the American people, and we are also standing up for the world'.
He said that Mr. Trump has "well-deserved strong words for the Iranian regime" that he will also raise during a meeting of the UN Security Council on Wednesday.
The Trump administration has already moved to stop all funding for UNRWA, the United Nations agency that provides aid for Palestinian refugees. The Iranian leader accuses the US of adopting a hostile stance toward his country.
The accord, negotiated under Democratic US President Barack Obama, lifted most worldwide sanctions against Tehran in exchange for Iran curbing its nuclear programme.
Some Iranian insiders have said any talks between Mr Rouhani and Mr Trump would effectively kill the existing nuclear accord.
Mr Rouhani sharply criticised Mr Trump's decision to withdraw from the 2015 worldwide nuclear deal with Iran, which was negotiated under former United States president Barack Obama.
Trump says he looks forward to having a "great relationship" with Iran but "Iran has to change its tune".
This after the USA announced tariffs recently on another $200 billion in Chinese-made goods for a total, so far, of $250 billion. "Nobody should like it", Trump said.