"It's a completely different competition".
"The game on Saturday is going to be huge, the type of game means a lot", the Italian said.
"It's a hard draw for both teams".
Liverpool have made a sensational start to the season with a 100% record across all competitions, spanning seven games and will want to keep that run against their London rivals. It's a home game, floodlights, I like it [and it is] against very strong side, so it will be really interesting.
At his pre-match press conference on Tuesday, Klopp said when asked about Sarri: "It is the biggest change of system I ever saw in such a short period of time. Wow".
Liverpool are in the midst of a hard stretch of games which has seen them beat Tottenham Hotspur, Paris Saint-German and Southampton so far, but after the two Chelsea games they will travel to Napoli in the Champions League before hosting Manchester City in a huge Premier League clash.
"Maybe I will have to change 11 players, maybe only five".
"It's not about the other three competitions tomorrow night, it's exactly one we have to play in, not four, and that's how we will take it, with all concentration, all focus, all intensity, normal game", he said. "Wow, what a manager he is".
"People were always talking about City being clear and completely forgot Chelsea", he said. Outstanding football, and now doing it in a very interrupted pre-season [due to the World Cup]. Eden [Hazard] was not there, Giroud not there and a few players were out. Starting the season and you see immediately the impact?
"It's really good to watch and he's done a good job so far, I have to say". It won the title before, 80 per cent [of the players] won it twice, and they know how it works.
"But it will be a good team, believe me".