Mourinho has let his feelings known about such surfaces to UEFA but was keen to stress that it should not be an excuse, instead pointing to one of Switzerland's favourite sons Federer's versatility as inspiration.
Manchester United attempted to get accustomed to the plastic pitch that will await them when they take on Young Boys.
"I don't want to use that, especially before the match, as a possible excuse for a poor performance", Mourinho said.
"Everybody knows that he has a favourite surface, but he has also to win on the surfaces that he is not in love with, so we have to do it".
"We have to do it, but Antonio is the only one we need to protect with his clinical situation, apart from that we give everything and try to win".
United go into the match in good spirits having recovered from a shaky start to the domestic season by winning their last two league matches.
Mourinho wants United to join the Fed Express
"I'm not saying Jose Mourinho's wrong and he should play him, he shouldn't, Lukaku's better than him". "Of course he has".
'We decide not to play Antonio Valencia because his knee is not a knee that needs an artificial pitch at all. "So we brought [Luke] Shaw back into the squad, I told already he is playing tomorrow, and we have Diogo, [Ashley] Young and [Matteo] Darmian ready to play".
Federer, a 20-times Grand Slam champion, has won tournaments on every playing surface in his sport, and Mourinho spoke of his admiration for the Swiss player's adaptability.
Mourinho said of the Young Boys match: "He's selected for the game".
"I don't think we have specialist players in certain positions anymore; you see full-backs play as wing-backs, wingers as number 10s and so on", said Hargreaves.
"We have [Romelu] Lukaku, Rashford, [Juan] Mata, Alexis [Sanchez], [Anthony] Martial and they can not all play together".
Speaking to Sky Sports, Carragher said: "Liverpool have got Brazil's centre-forward, Man City have got one of the greatest Argentinian centre-forwards of all time, Chelsea have got two strikers who have question marks against them - one's a World Cup victor, the other one's played for Real Madrid and Juventus - Arsenal have got two £50million strikers and United have got (Romelu) Lukaku".