In what was a brilliant display of skill, finesse and power, Pulisic showed out in front of a passionate crowd at Bank of America Stadium in Charlotte, N.C.
It seems Matip is now faced with yet another injury concern, which is sure to come as a blow to Klopp as he continues to gear his Reds side up for the upcoming season.
It seems like the 25-year-old is a long way off recapturing any semblance of composure and he made another error against Borussia Dortmund on Sunday night, although he was let off the hook on this occasion. But then Dortmund scored a second and then a third.
The American then took the ball off Mario Gotze and duly dispatched from the spot to draw Dortmund level and give the USA crowd a goal from one of their own.
Liverpool's pressure continued to grow, though, and Sheyi Ojo should have added a second shortly after the hour mark when he was slipped clean through on goal, only to see his finish saved by the feet of Hitz and bounce up against the crossbar before the ball was cleared away off the head of Naby Keita from the rebound. "I think he'll be fine".
Jürgen Klopp told his post-match press conference: "It's not the same injury".
However, Dortmund managed to snatch the winning goal in the 89th minute as Pulisic completed his brace by drilling home a left-footed effort into the far corner after being picked out by Marcel Schelzer.
Pulisic nearly completed the hat trick in the 93rd minute but his blast from in close was stopped and the rebound went to teammate Jacob Bruun Larsen who deposited it into the empty net as Dortmund improved to 2-0 in the 18-team pre-season tournament.
Karius' second mistake came in injury time when Liverpool were 2-1 behind.
And now, the latest addition to his growing list of mistakes may be one of the last he gets the opportunity to make with new signing Alisson joining up with Liverpool at the start of next week.