Federer was first on Centre Court on Monday for what is known as Wimbledon's "Manic Monday", in which all 32 remaining singles players vie for a place in the quarterfinals.
Federer fired another warning to his title rivals in another very complete performance.
Roger Federer, who has yet to lose a set during this tournament, celebrates his 6-0, 7-5, 6-4 win over France's Adrian Mannarino on Monday to advance to the quarterfinals at Wimbledon.
Mannarino was never allowed to settle as an ultra-aggressive Federer executed some sublime winners from the back of the court.
In the first set when Federer led 2-0, he just defended a return from the Frenchman.
Mannarino, world No 26, upped his level in the following two sets and had three break-point opportunities during the third set but saved them all before breaking and serving out for victory.
The eight-time champion earned his latest win with maximum efficiency on Centre Court, particularly during a 16-minute first set, where the top-seeded Federer lost just five points.
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Latvia's Jelena Ostapenko is only 21 but is already a Grand Slam champion, having won the French Open previous year, and she credits ballroom dancing for helping with her footwork.
Should No. 103 Mackenzie McDonald defeat former runner-up Milos Raonic later Monday, it will be the first time since 2000 that two men outside the top 100 have made the Wimbledon quarterfinals.
"I don't know if I'll be going anywhere concert-wise tomorrow", he said.
"I honestly think that I'm going to win one". The only different thing is that it's Federer in front of me, and he's a really good opponent.
The men's Grand Slam record is held by Bjorn Borg, who won 41 sets in a row at Roland Garros between 1979 and 1981.
Three-time champion Novak Djokovic, seeded a lowly 12 this year, can make his 10th Wimbledon quarter-final if he defeats unseeded Karen Khachanov, the world number 40 from Russian Federation.
Monfils and Anderson have yet to get to the quarter-finals at Wimbledon, although the French shotmaker may just be the slight favourite as he has a 5-0 winning record over the big South African.
Bertens and Pliskova had reached the fourth round at Wimbledon for the first time. "I feel like the more experienced you are, the more you can deal with those better".
All England Club chief executive Richard Lewis, meanwhile, says Wimbledon organisers will not alter the schedule to accommodate a potential England final appearance. No. 14 Daria Kasatkina, 2017 French Open champion Jelena Ostapenko vs. Dominika Cibulkova, and No. 13 Julia Goerges vs.
The 12th game went to deuce eight times, with Simon saving four set points, as Del Potro failed to take his chances, the worst when he put an easy volley over the baseline with the court wide open.