The cuts will be focused on management, administration and support roles in the United Kingdom with core engineering jobs expected to escape the efficiency measures.
Britain's Rolls-Royce (RR.L) said it would cut 4,600 jobs primarily in the United Kingdom as part of a plan to simplify its business and save 400 million pounds ($536 million) a year by the end of 2020.
The cuts announced Thursday, which represent 8.4% of the company's 55,000 workforce, will be implemented out over the next 24 months, the company said.
Rolls has faced a tough trading environment in recent years on weak demand for its plane engines and marine power systems.
Recent annual figures showed Rolls-Royce returned to profit previous year with a pre-tax surplus of £4.9 billion, thanks to a £2.6 billion accounting boost from the recent strengthening of the pound.
The chief executive, Warren East, said: "We have made progress in improving our day-to-day operations and strengthening our leadership, and are now turning to reduce the complexity that often slows us down and leads to duplication of effort".
Speaking to the BBC, East said he saw opportunities in China.
Rolls said the latest round of restructuring was expected to cost the group £500 million.
"We look at China and we see an opportunity there for aircraft engine. that's where a lot of opportunities are".