Insiders tell TMZ that the 48-year-old "Dodgeball" star was arrested after being stopped at a routine police checkpoint while driving with a passenger.
According to TMZ, Vince is now still in police custody. His passenger was also arrested and charged with resisting, delaying or obstructing officers.
Representatives for Vaughn did not immediately respond to requests for comment. If he is charged with a DUI, it will be his first.
The Delivery Man actor was previously arrested for his involvement in a 2001 bar brawl in Wilmington, North Carolina.
This story will be updated with developments.