Embiid has already been ruled out of Game 2, however, so Whiteside's role should be limited Monday night.
After the Sixers rode an historical string of hot shooting to victory in the opener, they struggled to get open looks to fall Monday. A win ties the series at 1-1 before heading back to Miami for the next two games in the series.
The series will head south to Miami for game three and four on Thursday, April 18 and Saturday, April 21.
The Sixers opened Monday's contest on a tear.
Then Wade took over.
The 15-year National Basketball Association veteran opened the game going 7-of-7 from the field, putting up 21 points in the first half.
The Heat outscored the Sixers 34-13 in the second quarter to take a 14-point lead into the locker room.
The loss ends the Sixers' 17-game winning streak but it doesn't sap the team of hope for a deep playoff run.
The Heat guaranteed at Game 5 next Tuesday in Philadelphia.
That also didn't work out well, which ended in a disaster, and the team initiating the largest trade and team turnover at once in NBA History, but for Wade, it landed him back to where he belonged, with the Heat.
The 76ers lose Game 2 to the Miami Heat 113-103.