With a red carpet dyed black by actresses dressed in a color-coordinated statement against sexual harassment and gender inequality, the Golden Globes confronted the post-Harvey Weinstein era with a ceremony at turns protest rally and party, atonement and celebration.
"What I know for sure is that speaking your truth is the most powerful tool we all have", she said.
The film had also been shut out of most of the Golden Globes nominations - nothing for screenwriter and director Jordan Peele, for example - so it losing Best Comedy/Musical to the equally adored Lady Bird wasn't a shock. They will compete with HBO's powerhouse "Game of Thrones", Hulu's much-publicized "The Handmaid's Tale" and NBC's hit "This is Us". "I'm especially proud and inspired by all the women who felt strong enough and empowered enough to speak up and share their personal stories.This year, we became the story".
Who were the main winners of the night?
Women in the industry have launched the Time's Up movement to address gender disparity and abuse and nearly all of Hollywood - both women and men - turned up in black at the red carpet to show their support.
Alexander Skarsgard and Laura Dern both took home the awards for Best Supporting Actor and Actress in a TV Series, Miniseries, or TV Movie, respectively.
In a stark contrast to any previous years where talk centred around who you were wearing, the 2018 Golden Globes conveyed the "why" rather than "who" message. And in many cases this year, those awards went to films and TV shows starring or created by women and people of colour, shining a light on the very issues the #TimesUp campaign sought to highlight.
Frances McDormand was among the winners on the night, taking home the best actress award for Three Billboards Outside Ebbing, Missouri. "She would say to friends, "I go to bed with Winston Churchill and wake up with Gary Oldman".
The Best Director category was jam-packed with deserving winners (although, as pointed out by Natalie Portman on the night, it was also noticeably all-male), with several major names not making the cut.
The theme was echoed by Laura Dern, victor of a best supporting actress for Big Little Lies, who said: "Many of us were taught not to tattle".
Oscar nominations will be announced the morning of January 23, and the winners revealed at the usual marathon ceremony in Los Angeles on March 4, hosted by Jimmy Kimmel for a second year, starting at 8 p.m. and broadcast live on ABC. Maisel's Rachel Brosnahan for best actress in a television series, musical or comedy; The Handmaid's Tale for best television series, drama; This Is Us' Sterling K. Brown for best actor in a television series, drama; The Disaster Artist's James Franco for best actor in a motion picture, comedy or musical; and I Tonya's Allison Janney for best actress in a supporting role, motion picture.
Greta Gerwig, whose directorial debut Lady Bird was named best musical or comedy film, could be seen being hugged by her film's star, Saoirse Ronan, as Streisand made her comments.