Samuel was hurt when hurt when a defender rolled over his left ankle after an incompletion in the end zone early in the third quarter.
Panthers rookie WR Curtis Samuel suffered ligament damage in his ankle and is out for the season, per source.
The Panthers traded No. 1 wideout Kelvin Benjamin to Buffalo two weeks ago in part to get more speed on the field.
"There were a lot of good things", offensive coordinator Mike Shula said Tuesday of Samuel's game, according to the Panthers' official website. "Guys coming in and doing their jobs and knowing their assignments". Carolina's offense has excelled since then, racking up a franchise record 548 yards and 30 first downs against Miami. He compiled career-high 5 catches for 45 yards before going down.
"One of the best things that happened after Curtis [went out] was we didn't feel we missed a beat, " Shula said.
"It's kind of a collective effort", Shula said.
The Panthers have only four other receivers on their active roster - Devin Funchess, Russell Shepard, Kaelin Clay and Brenton Bersin - but Damiere Boyd is eligible to come off injured reserve for the team's game against the Saints on December 3.