The "One Love Manchester" benefit concert raised at least $9 million for the victims and families of the May 22 bombing outside Grande's show. She closed the show with a stirring rendition of Somewhere Over the Rainbow.
"Thank you to all those who helped in any way that night in Manchester".
Other stars who took to the stage included Pharrell Williams, One Direction star Niall Horan, Justin Bieber, Little Mix and Imogen Heap while Katy Perry performed her hit Roar, saying: "We will not be silenced, Manchester".
The mood at the concert has been described as sombre, especially one day removed from several terror attacks in London.
Justin Bieber told us "love always wins in the end" as he delivered stripped-back versions of "Love Yourself" and "Cold Water", before Coldplay coated us in multi-coloured confetti.
The singer said: "I want to thank you all for being here today".
The attack killed 22 and wounded dozens. The song includes the lyrics: 'But you are not alone in this, and you are not alone in this, as brothers we will stand and we'll hold your hand'.
Ariana paid an emotional tribute to those who had lost their lives as she said performed for the final time. Where is the Love was released back in 2003 by the Black Eyed Peas, and 14 years later there's still just as much suffering in the world.
In an interview with the BBC, Cyrus said she thought the "Into You" singer had found her calling in organizing the event.
He says: "All of our hearts are with Manchester and the UK. All we feel here tonight is love, resilience, positivity", Williams said before he launched into his hit song, "Happy" with an assist from Miley Cyrus.
The concert reportedly brought in thousands of attendees in Manchester. Spirits were high as security guards encouraged people to dance while outside, bus drivers offered people free lifts as "We Love MCR" beamed bright emblazoned on their screens.
Nicki went to Instagram Sunday (June 4) to speak on Grande's headline-generating event.
Grande seemed overcome by emotion throughout the show which came less than 24 hours after seven people were killed and 48 injured in a terror attack in London Bridge.
The show was broadcast across the globe and proceeds from the concert will go to an emergency fund set up by the city of Manchester and the British Red Cross.